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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 14 I 20 kDa                                                     Uniprot ID: Q9ULR5 

Background:

Various PABP-interacting proteins bind to and regulate the activity of polyadenylate-binding protein (PABP), an essential, well-conserved, multifunctional protein involved in translational initiation, mRNA biogenesis and degradation. PABP enhances translation by circularizing mRNA through its interaction with the translation initiation factor eIF4G and mRNA's poly(A) tail. PABP-interacting proteins include PaiP1, a translational stimulator, and Paip2a and Paip2b, translational inhibitors. Paip1 is thought to act as a translational activator in 5' cap-dependent translation by interacting with PABP and the initiation factors eIF4A and eIF3, whereas Paip2 decreases the affinity of PABP for polyadenylate RNA, and disrupts the repeating structure of poly(A) ribonucleoprotein. Paip2b (poly(A) binding protein interacting protein 2B) is a 123 amino acid protein that may be involved in regulating PABP activity.

Other Names:

Polyadenylate-binding protein-interacting protein 2B, PABP-interacting protein 2B, PAIP-2B, Poly(A)-binding protein-interacting protein 2B, KIAA1155

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing N-terminal region of human PAIP2B. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: