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Quantity: 100 ug                                                                   Application: ELISA

Predicted M.W.: 54 kDa                                                        Uniprot ID: P45452

Background:

Matrix metallopeptidase 13 (collagenase 3) (MMP13) is a zinc-dependent endopeptidase that belongs to the matrix metalloproteinase (MMP) family.  Members of the MMP family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, migration and tissue remodeling. MMP13 has been implicated in disease progressions, including arthritis, chronic ulcers and metastasis.  Most MMPs are secreted as zymogens requiring activation by an extracellular proteinase.  MMP13 cleaves type II collagen more efficiently than types I and III.  It may play a role in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis.                                                      

Other Names:

CLG3, MANDP1

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human MMP13.  Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications: 

ELISA:  1:1,000- 1:10,000 (detect native recombinant protein in a direct ELISA assay). 

              Suitable for using as ELISA capture or detection antibodies.