Products

R0952-2 - CADM1 (C) Antibody, Rabbit Polyclonal

Catalog No. R0952-2
Product Name CADM1 (C) Antibody, Rabbit Polyclonal
Price $249
  
 

Quantity: 100 ul                                                                                          Application: WB

Predicted | Observed MW: 49 kDa                                                              Uniprot ID: Q9BY67 


Background:

Cell adhesion molecule 1 (CADM1) is a single-pass type I membrane protein belonging to the nectin family. CADM1 mediates homophilic cell-cell adhesion in a Ca2+-independent manner. CADM1 also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.

Other Names:

Cell adhesion molecule 1, Immunoglobulin superfamily member 4, IgSF4, Nectin-like protein 2, NECL-2, Spermatogenic immunoglobulin superfamily, SgIgSF, Synaptic cell adhesion molecule, SynCAM, Tumor suppressor in lung cancer 1, TSLC-1, IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human CADM1. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data:

CADM1 Antibody Western (Abiocode)

Fig 1.  Western blot of total cell extracts
from A) mouse brain; B) human HeLa;
using anti-CADM1 (C) (R0952-2) at RT
for 2 h.