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R0959-1 - IDH2 (N) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted M.W.: 51 kDa Uniprot ID: P48735 Background: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent which localize to the mitochondrial matrix; and two NADP(+)-dependent, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. IDH2 is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria, which plays a role in intermediary metabolism and energy production. IDH2 may tightly associate or interact with the pyruvate dehydrogenase complex. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2), a neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Other Names: Isocitrate dehydrogenase [NADP] mitochondrial, IDH, ICD-M, IDP, NADP(+)-specific ICDH, Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human IDH2. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:5,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: |