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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 32 I 40 kDa                                                     Uniprot ID: O75461

Background:

E2F6 is a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. E2F6 is atypical because it lacks the transactivation and tumor suppressor protein association domains. E2F6 contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. E2F6 is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max.

Other Names:

Transcription factor E2F6, E2F-6

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human E2F6. Antibodies were purified by affinity purification using immunogen.

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: