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Quantity: 100 ul                                                                                             Application: WB

Predicted I Observed M.W.: 101 kDa                                                          Uniprot ID: Q9ULT6

Background:

E3 ubiquitin-protein ligase ZNRF3 is a single-pass type I membrane protein belonging to the ZNRF3 family. ZNRF3 is an E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. ZNRF3 acts on both canonical and non-canonical Wnt signaling pathway. Additionally, ZNRF3 acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Other Names:

E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, Zinc/RING finger protein 3, KIAA1133, RNF203

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human ZNRF3. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: