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R1578-2 - PDE3B (C) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB
Predicted I Observed M.W.: 124 I 130 kDa Uniprot ID: Q13370 Background: cGMP-inhibited 3',5'-cyclic phosphodiesterase B (PDE3B) is a multi-pass membrane protein that belongs to the cyclic nucleotide phosphodiesterase family. PDE3B is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. PDE3B assembles a signaling complex through simultaneous binding to RAPGEF3 and PIK3R6, in which the PI3K gamma complex is activated by RAPGEF3. PDE3B may play a role in fat metabolism and angiogenesis. Other Names: cGMP-inhibited 3',5'-cyclic phosphodiesterase B, CGIPDE1, CGIP1, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B, HcGIP1 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human PDE3B. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extracts from(A, C) human HeLa, (B) human Jurkat; using2 independent Abs against 2 distinct regionsof human PDE3B at RT for 2 h. |