Abiocode Logo
Products
Contact Us
- Telephone:
1-818-707-0309 - E-Mail:
Abiocode@Abiocode.com
R1958-1 - MAVS (N) Antibody, Rabbit Polyclonal
|
Quantity: 100 ul Application: WB Predicted I Observed M.W.: 57 I 75 kDa Uniprot ID: Q7Z434 Background: Mitochondrial antiviral-signaling protein (MAVS) is required for innate immune defense against viruses. Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. MAVS may activate the same pathways following detection of extracellular dsRNA by TLR3 and may also protect cells from apoptosis. Other Names: Mitochondrial antiviral-signaling protein, MAVS, CARD adapter inducing interferon beta, Cardif, Interferon beta promoter stimulator protein 1, IPS-1, Putative NF-kappa-B-activating protein 031N, Virus-induced-signaling adapter, VISA, IPS1, KIAA1271, VISA Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human MAVS. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: (A) mouse brain, (B) mouse thymus; using anti-MAVS (N) (R1958-1) at RT for 2 h. |