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R1762-1 - DDX17 (N) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB, IP Predicted I Observed M.W.: 80 kDa Uniprot ID: Q92841 Background: Probable ATP-dependent RNA helicase DDX17 belongs to the DEAD box helicase family and the DDX5/DBP2 subfamily. DDX17 is an RNA-dependent ATPase activity. DDX17 is involved in transcriptional regulation and is a transcriptional coactivator for estrogen receptor ESR1. DDX17 increases ESR1 AF-1 domain-mediated transactivation. Additionally, DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is probably involved in skeletal muscle differentiation. Furthermore, DDX17 is required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation. Other Names: Probable ATP-dependent RNA helicase DDX17, DEAD box protein 17, DEAD box protein p72, RNA-dependent helicase p72 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human DDX17. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) IP: 1:100-1:200
*: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. (A) Western blot of total cell extracts from a. mouse brain, b. mouse thymus, c, e. human HeLa, d, f. human Jurkat; using 2 independent Abs against 2 distinct regions of human DDX17 at RT for 2 h. (B) Total extracts from human HeLa were immunoprecipitated (IP) with IgG or anti-DDX17 (N) (R1762-1); followed by WBwith the same Ab. |