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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 82 I 110 kDa                                                   Uniprot ID: O75175

Background:

CCR4-NOT transcription complex subunit 3 (CNOT3) belongs to the CNOT2/3/5 family. CNOT3 is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT3 may be involved in metabolic regulation; additionally, CNOT3 may also be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism.

Other Names:

CCR4-NOT transcription complex subunit 3, CCR4-associated factor 3, Leukocyte receptor cluster member 2, KIAA0691, LENG2, NOT3

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human CNOT3. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: