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R1594-1 - ERCC2 (N) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 87 kDa Uniprot ID: P18074 Background: The nucleotide excision repair pathway is a mechanism to repair damage to DNA. DNA excision repair protein ERCC2 is involved in transcription-coupled nucleotide excision repair and is an integral member of the basal transcription factor BTF2/TFIIH complex. ERCC2 has ATP-dependent DNA helicase activity and belongs to the RAD3/XPD subfamily of helicases. Defects in ERCC2 can result in three different disorders, the cancer-prone syndrome xeroderma pigmentosum complementation group D, trichothiodystrophy, and Cockayne syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene [provided by RefSeq]. Other Names: TFIIH basal transcription factor complex helicase XPD subunit, Basic transcription factor 2 80 kDa subunit, BTF2 p80, CXPD, DNA excision repair protein ERCC-2, DNA repair protein complementing XP-D cells, TFIIH basal transcription factor complex 80 kDa subunit, TFIIH 80 kDa subunit, TFIIH p80, Xeroderma pigmentosum group D-complementing protein, EM9, MAG, MGC102762, MGC126218, MGC126219, XPD Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human ERCC2. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: (A, C) human HeLa, (B, D) human Jurkat; using 2 independent Abs against 2 distinct regions of human ERCC2 at RT for 2 h. |