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R2849-vp - TMPRSS2 (vPairTM) Antibodies
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Predicted | Observed MW: 52 | 60 kDa Uniprot ID: O15393 Application: WB Quantity: 50 ul TMPRSS2 (N) (R2849-1) Rabbit Polyclonal Antibody & 50 ul TMPRSS2 (C) (R2849-2) Rabbit Polyclonal Antibody Product Introduction: vPairTM antibodies represent a pair of fully characterized antibodies that recognize two different regions of a target protein. The product is developed by Abiocode to address whether the signal observed truly represents the protein of interest, an often encountered issue in antibody-based assays. The use of a pair of fully characterized vPairTM antibodies in the same assay can validate signal specificity since vPairTM antibodies recognize two independent epitopes of the same protein. Different sets of vPairTM antibodies are developed at Abiocode to work with specific applications, including antibody arrays, Western blot, IP-Western, ChIP, IHC, and FACS. Background: Transmembrane protease serine 2 (TMPRSS2) belongs to the serine protease family. It contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. It was demonstrated that TMPRSS2 is up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage [provided by RefSeq]. Other Names: Transmembrane protease serine 2, Serine protease 10, PRSS10 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with GST-fusion proteins containing either the N-terminal [TMPRSS2 (N) (R2849-1)] or the C-terminal [TMPRSS2 (C) (R2949-2)] region of human TMPRSS2. Antibodies were purified by affinity purification using immunogen. Species Specificity: Human, Mouse Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extracts fromA, C) mouse brain, B, D) mouse thymus; using 2 independent Abs against 2 distinct regions of human TMPRSS2 at RT for 2 h. |