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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 183 I 230 kDa                                                 Uniprot ID: Q8WXG6

Background:

MAP kinase-activating death domain protein (MADD) plays a significant role in regulating cell proliferation, survival and death through alternative mRNA splicing. MADD converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms. MADD is a component of the TNFRSF1A signaling complex: MADD links TNFRSF1A with MAP kinase activation. MADD also plays an important regulatory role in physiological cell death (TNF-alpha-induced, caspase-mediated apoptosis).

Other Names:

MAP kinase-activating death domain protein, Differentially expressed in normal and neoplastic cells, Insulinoma glucagonoma clone 20, Rab3 GDP/GTP exchange factor, DENN, IG20, KIAA0358

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human MADD. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: