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R2928-1 - FOXO3 (N) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 71 I 80 kDa Uniprot ID: O43524 Background: Forkhead box protein O3 (FOXO3) is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. FOXO3 recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO3 participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation. Other Names: Forkhead box protein O3, AF6q21 protein, Forkhead in rhabdomyosarcoma-like 1, FKHRL1, FOXO3A Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human FOXO3. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extracts from A, C) mousethymus, B, D) human HeLa; E) human Jurkat; using 2 independent Abs against 2 distinct regions of human FOXO3 at RT for 2 h. |