Abiocode Logo

Quantity: 100 ul                                                                                       Application: WB

Predicted I Observed M.W.: 44 kDa                                                         Uniprot ID: Q8WTW4

Background:

Nitrogen permease regulator 2-like protein (NPRL2) suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. NPRL2 down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. NPRL2 may act as a tumor suppressor, and it suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, NPRl2 is an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

Other Names:

NPR2, NPR2L, TUSC4, Tumor suppressor candidate 4, G21 protein, Gene 21 protein, NPR2-like protein, Nitrogen permease regulator 2-like protein

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human NPRL2. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: