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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 314 kDa                                                          Uniprot ID: Q14643

Background:

Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) is a multi-pass membrane protein located in endoplasmic reticulum (ER) membrane. ITPR1 is an intracellular channel that mediates calcium release from the ER following stimulation by inositol 1,4,5-trisphosphate. ITPR1 plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

Other Names:

Inositol 1,4,5-trisphosphate receptor type 1, IP3 receptor isoform 1, IP3R 1, InsP3R1, Type 1 inositol 1,4,5-trisphosphate receptor, Type 1 InsP3 receptor, INSP3R1

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human ITPR1. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:500-1:2,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: