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R2450-1 - HGS (N) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 86 kDa Uniprot ID: O14964 Background: Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) is a peripheral membrane protein involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, HGS suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. HGS could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. Other Names: Hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, Protein pp110 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human HGS. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extractsfrom A) mouse brain, B) mouse thymus, C) human HeLa, D) human Jurkat; using anti-HGS (N) (R2450-1) at RT for 2 h. |