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Quantity: 100 ul                                                                                 Application: WB

Predicted I Observed M.W.: 39 kDa                                                    Uniprot ID: P58012

Background:

Forkhead box protein L2 (FOXL2) is a transcriptional regulator essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. FOXL2 prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). FOXL2 also has apoptotic activity in ovarian cells and it suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. FOXL2 is a regulator of CYP19 expression, and it participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element.

Other Names:

Forkhead box protein L2

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human FOXL2. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications:

WB: 1:500-1:2,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: