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Quantity: 100 ul                                                                                        Application: WB

Predicted | Observed MW: 116 kDa                                                          Uniprot ID: P06756 

Background:

Integrin, alpha V (ITGAV) is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAV undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. ITGAV has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. ITGAV interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that ITGAV may regulate angiogenesis and cancer progression.

Other Names:

Integrin, alpha V, CD51, MSK8, VNRA, VTNR, Vitronectin receptor subunit alpha

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human ITGAV. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:500-1:2,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: