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Quantity: 100 ul                                                                                     Application: WB

Predicted I Observed M.W.: 71 kDa                                                       Uniprot ID: Q15326

Background:

Zinc finger MYND domain-containing protein 11 (ZMYND11) is a chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. ZMYND11 does not bind other histone H3 subtypes (H3.1 or H3.2). ZMYND11 co-localizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. ZMYND11 also acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.

Other Names:

Zinc finger MYND domain-containing protein 11, Adenovirus 5 E1A-binding protein, Bone morphogenetic protein receptor-associated molecule 1, Protein BS69, BRAM1, BS69 

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human ZMYND11. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:500-1:2,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: