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Quantity: 100 ul                                                                                 Application: WB

Predicted M.W.: 176 kDa                                                                   Uniprot ID: P41229

Background:

Lysine-specific demethylase 5C (KDM5C) is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. KDM5C does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. KDM5C demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. KDM5C has been shown to participate in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements.

Other Names:

Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169, DXS1272E, JARID1C, SMCX, XE169

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human KDM5C. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications: 

WB: 1:1,000-1:5,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: