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R0231-vp - KDM5C (vPairTM) Antibodies
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Predicted M.W.: 176 kDa Uniprot ID: P41229 Application: WB Quantity: 50 ul KDM5C (N) (R0231-1) Rabbit Polyclonal Antibody & 50 ul KDM5C (C) (R0231-2) Rabbit Polyclonal Antibody Product Introduction: vPairTM antibodies represent a pair of fully characterized antibodies that recognize two different regions of a target protein. The product is developed by Abiocode to address whether the signal observed truly represents the protein of interest, an often encountered issue in antibody-based assays. The use of a pair of fully characterized vPairTM antibodies in the same assay can validate signal specificity since vPairTM antibodies recognize two independent epitopes of the same protein. Different sets of vPairTM antibodies are developed at Abiocode to work with specific applications, including antibody arrays, Western blot, IP-Western, ChIP, IHC, and FACS. Background: Lysine-specific demethylase 5C (KDM5C) is a histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. KDM5C does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. KDM5C demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. KDM5C has been shown to participate in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Other Names: Lysine-specific demethylase 5C, Histone demethylase JARID1C, Jumonji/ARID domain-containing protein 1C, Protein SmcX, Protein Xe169, DXS1272E, JARID1C, SMCX, XE169 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing either the N-terminal [KDM5C (N) (R0231-1)] or the C-terminal [KDM5C (C) (R0231-2)] regions of human KDM5C. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:1,000-1:5,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications.
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