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R0225-2 - KDM6A (N2) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted M.W.: 154 kDa Uniprot ID: O15550 Background: Lysine-specific demethylase 6A (KDM6A) is a histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. KDM6A can demethylate trimethylated and dimethylated but not monomethylated H3 'Lys-27', and it plays a central role in the regulation of posterior development by regulating HOX gene expression. KDM6A also regulates the recruitment of the PRC1 complex and monoubiquitination of histone H2A. Other Names: Lysine-specific demethylase 6A, Histone demethylase UTX, Ubiquitously-transcribed TPR protein on the X chromosome, Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein, UTX Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human KDM6A, which is distinct from the antigen for KDM6A (N1) (R0225-1). Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:1,000-1:5,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications.
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