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Quantity: 100 ul                                                                                Application: WB

Predicted M.W.: 53 kDa                                                                    Uniprot ID: Q9NPF5

Background:

DNA methyltransferase 1-associated protein 1 (DMAP1) is a subunit of several distinct complexes involved in the repression or activation of transcription. DMAP1 can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1 (DNMT1). During late S phase, histone deacetylase 2 (HDAC2) is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. DMAP1 is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others.

Other Names:

DNA methyltransferase 1-associated protein 1, DNMAP1, DNMT1-associated protein 1, KIAA1425

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human DMAP1. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications: 

WB: 1:1,000-1:5,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: