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R0746-2 - NOTCH2 (C2) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted M.W.: 265 kDa Uniprot ID: Q04721 Background: Neurogenic locus notch homolog protein 2 (NOTCH2) is a single-pass type I membrane protein that belongs to the NOTCH family. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. It is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, NOTCH2 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Defects in NOTCH2 cause Alagille syndrome type 2 (ALGS2) and Hajdu-Cheney syndrome (HJCYS). Other Names: Neurogenic locus notch homolog protein 2, hN2, Notch 2 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human NOTCH2. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:500-1:1,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications.
Product Data: Fig 1. Western blot of total cell extracts from human 293T, using (A) Ab (R0746-2), (B) Ab (R0746-3) at RT for 2 h.
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