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Quantity: 100 ul                                                                                             Application: WB

Predicted I Observed M.W.: 23 I 28 kDa                                                     Uniprot ID: Q9Y6W8 

Background:

Inducible T-cell costimulator (ICOS) enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. ICOS is essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. ICOS does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. ICOS prevents the apoptosis of pre-activated T-cells and plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Defects in ICOS are the cause of immunodeficiency common variable type 1.

Other Names:

Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human ICOS. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: