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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 191 kDa                                                          Uniprot ID: Q14999

Background:

CUL7 is a component of a probable SCF-like E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. CUL7 probably plays a role in the degradation of proteins involved in endothelial proliferation and/or differentiation. In vitro, complexes of CUL7 with either CUL9 or FBXW8 or TP53 contain E3 ubiquitin-protein ligase activity. CUL7 is highly expressed in fetal kidney and adult skeletal muscle. Defects in CUL7 are the cause of 3M syndrome type 1.

Other Names:

KIAA0076, dJ20C7.5

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human CUL7. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: