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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 107 kDa                                                          Uniprot ID: P08235 

Background:

NR3C2 is the receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. NR3C2 binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.  Defects in NR3C2 are a cause of pseudohypoaldosteronism 1, autosomal dominant.  Defects in NR3C2 can also cause early-onset hypertension with severe exacerbation in pregnancy.

Other Names:

Mineralocorticoid receptor, MR, Nuclear receptor subfamily 3 group C member 2, MCR, MLR

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing N-terminal region of human NR3C2. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: