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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 54 I 58 kDa                                                     Uniprot ID: P98177

Background:

FOXO4 is the transcription factor involved in the regulation of the insulin signaling pathway. FOXO4 binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO4 down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. FOXO4 is also involved in negative regulation of the cell cycle. FOXO4 is involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Other Names:

Forkhead box protein O4, Fork head domain transcription factor AFX1, AFX, AFX1, MLLT7

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human FOXO4. Antibodies were purified by affinity purification using immunogen.

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: