Abiocode Logo

Quantity: 100 ul                                                                                    Application: WB

Predicted I Observed M.W.: 100 I 100, 66 kDa                                      Uniprot ID: Q9HB75

Background:

P53-induced protein with a death domain (PIDD ) promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. PIDD associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. PIDD also associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which is an important regulator in apoptotic pathway.

Other Names:

p53-induced protein with a death domain, Leucine-rich repeat and death domain-containing protein, LRDD

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human PIDD. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: