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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 32 kDa                                                            Uniprot ID: P70295

Background:

Ancient ubiquitous protein 1 (AUP1) is a single-pass type III membrane protein located at the cytoplamic side of the Endoplasmic reticulum membrane. AUP1 may play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.  AUP1 contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding to ubiquitin-conjugating enzymes. AUP1 has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signaling in platelets and megakaryocytes that leads to the platelet aggregation and thrombus formation.

Other Names:

Ancient ubiquitous protein 1

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of mouse AUP1. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: