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Quantity: 100 ul                                                                               Application: WB

Predicted I Observed M.W.: 48 kDa                                                 Uniprot ID: Q9R229

Background: 

Bone morphogenetic protein 10 (BMP10) belongs to the TGF-beta family. BMP10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. BMP10 acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Additionally, BMP10 inhibits endothelial cell migration and growth. BMP10 may reduce cell migration and cell matrix adhesion in breast cancer cell line.

Other Names:

Bone morphogenetic protein 10, BMP10

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of mouse BMP10. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: