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R0258-2 - MMS21 (C) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted M.W.: 28 kDa Uniprot ID: Q96MF7 Background: MMS21 is also known as E3 SUMO-protein ligase NSE2E3, which is a SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. MMS21 acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. The SUMO protein-ligase activity of MMS21 is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair. Other Names: E3 SUMO-protein ligase NSE2, MMS21 homolog, hMMS21, Non-structural maintenance of chromosomes element 2 homolog, Non-SMC element 2 homolog, NSMCE2, C8orf36, MMS21 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human MMS21. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:1,000-1:5,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications.
Product Data: Fig 1. Western blot of total cell extracts from human MCF7, using 2 independent Abs against 2 distinct regions of human MMS21 [A: R0258-1 (N-terminal); B: R0258-2 (C-terminal)] at RT for 2 h. The observed M.W. of MMS21 is approximately 46 kD.
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