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Quantity: 100 ul                                                                                 Application: WB

Predicted M.W.: 66 kDa                                                                    Uniprot ID: P03372

Background:

Estrogen receptor 1 (ESR1) belongs to the nuclear hormone receptor family, NR3 subfamily. ESR1 is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding and activation of transcription. ESR1 localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, and they also play a role in other tissues such as bone. In addition, estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Other Names:

Estrogen receptor, ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, ESR, NR3A1

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human ESR1. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications: 

WB: 1:1,000-1:5,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: