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Quantity: 100 ul                                                                                             Application: WB

Predicted | Observed MW: 73 kDa                                                              Uniprot ID: Q8C2K1

Background:

Differentially expressed in FDCP 6 (DEF6) is also known as SWAP-70-like adapter of T-cells  (SLAT), which is a phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF). DEF6 plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42, and regulates cell morphology in cooperation with activated RAC1. DEF6 also plays a role in Th2 (T helper cells) development and/or activation by interfering with ZAP70 signaling. DEF6 is required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of sytemic autoimmunity. Defects in DEF6 results in spontaneous development of a lupus-like syndrome in aging female mice.

Other Names:

Differentially expressed in FDCP 6, DEF-6, RF4-binding protein, SWAP-70-like adapter of T-cells, Ibp, Slat

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of mouse DEF6. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Mouse

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: