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Quantity: 100 ul                                                                                           Application: WB

Predicted I Observed M.W.: 43 I 46 kDa                                                      Uniprot ID: P21453

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Background:

Sphingosine 1-phosphate receptor 1 (S1PR1) is a multi-pass cell membrane protein that belongs to the G-protein coupled receptor 1 family. S1PR1 is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This inducible epithelial cell G-protein-coupled receptor may be involved in the processes that regulate the differentiation of endothelial cells. S1PR1 seems to be coupled to the G(i) subclass of heteromeric G proteins.

Other Names:

Sphingosine 1-phosphate receptor 1, S1P receptor 1, S1P1, Endothelial differentiation G-protein coupled receptor 1, Sphingosine 1-phosphate receptor Edg-1, S1P receptor Edg-1, CD363

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the middle region of human S1PR1. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data:

Fig 1. Western blot of total cell extracts from

human Jurkat; using anti-S1PR1 (M) (R1357-1)

at RT for 2 h.