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R2373-2 - PPP2CA (C) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 36 I 30 kDa Uniprot ID: P67775 Background: PPP2CA, serine/theonine-protein phosphatase 2A catalytic subunit alpha isoform, is the major phosphatase for microtubule-associated proteins (MAPs). PPP2CA can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. PPP2CA cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. PPP2CA can dephosphorylate SV40 large T antigen and p53/TP53. PPP2CA activates RAF1 by dephosphorylating it at 'Ser-259'. Other Names: Replication protein C, PP2Calpha, PP2A alpha, PP2A-alpha Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human PPP2CA. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extracts from (A, D)mouse brain, (B, E) mouse thymus, (C, F) human HeLa; using 2 independent Abs against 2 distinct regions of human PPP2CA at RT for 2 h. |