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R0070-1 - HP1a (M) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted M.W.: 22 kDa Uniprot ID: Q61686 Background: Heterochromatin protein 1-alpha (HP1a) is a highly conserved nonhistone protein belonging to the heterochromatin protein family. The N-terminal chromodomain of HP1a binds to histone H3 tails methylated at ‘Lys-9’ (H3K9me), leading to epigenetic repression. Conversely, it is excluded from chromatin when ‘Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). It may interact with lamin-B receptor. HP1a is involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Other Names: Cbx5, HP1, 2610029O15Rik, C75991 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the middle region of mouse HP1a. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:5,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data:
Fig 1. Western blot of total cell extracts from mouse thymus, using Ab (R0070-1) at RT for 2 h. |