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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 78 I 120 kDa                                                   Uniprot ID: Q9UQF2 

Background:

Mitogen-activated protein kinase 8-interacting protein 1 (MAPK8IP1) is also known as C-Jun-amino-terminal kinase-interacting protein 1 (JIP1).  The JIP family of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module.  MAPK8IP1 is required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. MAPK8IP1 may also participate in ApoER2-specific reelin signaling.  MAKP8IP1 is highly expressed in brain and appears to have a role in cell signaling in mature and developing nerve terminals.  It may also function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. MAPK8IP1 is also expressed in the pancreas, testis and prostate.  It regulates GLUT2 gene expression and functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response. Defects in MAPK8IP1 are a cause of non-insulin-dependent diabetes mellitus (NIDDM).

Other Names:

C-Jun-amino-terminal kinase-interacting protein 1, JIP-1, JNK-interacting protein 1, Islet-brain 1, IB-1,
JNK MAP kinase scaffold protein 1, Mitogen-activated protein kinase 8-interacting protein 1, IB1, JIP1, PRKM8IP

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing N-terminal region of human MAPK8IP1. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications. 

Species Specificity:

Human

Product Data: