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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 118 kDa                                                          Uniprot ID: Q9UPP1

Background:

PHD finger protein 8 (PHF8) is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. PHF8 requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene [provided by RefSeq].

Other Names:

Histone lysine demethylase PHF8, PHD finger protein 8, KIAA1111, ZNF422, JHDM1F

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the middle region of human PHF8. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: