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R2676-2 - PTCH1 (C) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 160 I 210 kDa Uniprot ID: Q13635 Background: PTCH1 acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. PTCH1 seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Defects in PTCH1 may cause basal cell nevus syndrome, sporadic basal cell carcinoma, holoprosencephaly type 7. Other Names: Protein patched homolog 1, PTC, PTC1, PTCH, BCNS, NBCCS Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human PTCH1. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extracts from(A) human HeLa, (B) human Jurkat; using anti-PTCH1 (C) (R2676-2) at RT for 2 h. |