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R1789-2 - PELI1 (C) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB
Predicted | Observed M.W.: 46 I 54 kDa Uniprot ID: Q96FA3 Background: E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. PELI1 is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation. Other Names: E3 ubiquitin-protein ligase pellino homolog 1, Pellino-1, Pellino-related intracellular-signaling molecule, PRISM
Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human PELI1. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extracts from(A) mouse brain, (B) human Jurkat, (C) humanHeLa; using 2 independent Abs against 2 distinctregions of human PELI1 at RT for 2 h |