Products

R1578-1b - PDE3B (N) Antibody, Rabbit Polyclonal

Catalog No. R1578-1b
Product Name PDE3B (N) Antibody, Rabbit Polyclonal
Price $219
  
 

Quantity: 100 ul                                                                                             Application: WB

Predicted I Observed M.W.: 124 I 130 kDa                                                 Uniprot ID: Q13370


Background:

cGMP-inhibited 3',5'-cyclic phosphodiesterase B (PDE3B) is a multi-pass membrane protein that belongs to the cyclic nucleotide phosphodiesterase family. PDE3B is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes.  PDE3B assembles a signaling complex through simultaneous binding to RAPGEF3 and PIK3R6, in which the PI3K gamma complex is activated by RAPGEF3. PDE3B may play a role in fat metabolism and angiogenesis.

Other Names:

cGMP-inhibited 3',5'-cyclic phosphodiesterase B, CGIPDE1, CGIP1, Cyclic GMP-inhibited phosphodiesterase B, CGI-PDE B, HcGIP1

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human PDE3B. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications: 

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data:

PDE3B Antibody Western (Abiocode)

Fig 1. Western blot of total cell extracts from
(A, C) human HeLa, (B) human Jurkat; using
2 independent Abs against 2 distinct regions
of human PDE3B at RT for 2 h.