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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 64 kDa                                                            Uniprot ID: Q13114

Background:

TRAF3 regulates pathways leading to the activation of NF-kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. TRAF3 is part of signaling pathways leading to the production of cytokines and interferon. TRAF3 is required for normal antibody isotype switching from IgM to IgG. TRAF3 plays a role T-cell dependent immune responses. TRAF3 plays a role in the regulation of antiviral responses. TRAF3 is an essential constituent of several E3 ubiquitin-protein ligase complexes. TRAF3 may have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. TRAF3 inhibits activation of NF-kappa-B in response to LTBR stimulation. TRAF3 inhibits TRAF2-mediated activation of NF-kappa-B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. TRAF3 promotes ubiquitination and proteasomal degradation of MAP3K14.

Other Names:

TNF receptor-associated factor 3, CAP-1, CD40 receptor-associated factor 1, CRAF1, CD40-binding protein, CD40BP, LMP1-associated protein 1, LAP1, CAP1, CRAF1

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing N-terminal region of human TRAF3.  Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: