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R2550-2 - GPC3 (C) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 65 I 59, 66, 85 kDa Uniprot ID: Q9NQ94 Background: GPC3 is a cell surface proteoglycan that bears heparan sulfate. GPC3 inhibits the dipeptidyl peptidase activity of DPP4. GPC3 may be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. GPC3 may play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. GPC3 may regulate growth and tumor predisposition. Other Names: Glypican-3, GTR2-2, Intestinal protein, OCI-5MXR7, Cleaved into secreted glypican-3, OCI5, DGSX, SDYS, SGB, SGBS, SGBS1 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing C-terminal region of human GPC3. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extracts from A) mouse thymus,B) human HeLa, C) human Jurkat; using anti-GPC3 (C) (R2550-2) at RT for 2 h. This Ab recognizes the 59 kD and 66 kD isoforms of GPC3. The 85 kD form indicated by * may represent glycanated GPC3 (Capurro M. et al., JCS 125:3380). |