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R2618-2 - PRF1 (C) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 61 kDa Uniprot ID: P14222 Background: PRF1 plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. PRF1 plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. PRF1 can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. PRF1 promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Other Names: Perforin-1, P1, Cytolysin Lymphocyte pore-forming protein, PFP Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing C-terminal region of human PRF1. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: A) mouse thymus, B, C) human Jurkat; using 2 independent Abs against 2 distinct regions of human PRF1 at RT for 2 h. |