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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 44 I 46 kDa                                                     Uniprot ID: P36507

Background:

Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) belongs to the STE Ser/Thr protein kinase family and the MAP kinase subfamily. It may play a role in catalyzing the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. It may also activate the ERK1 and ERK2 MAP kinases. Mutations in MAP2K2 is related to cardiofaciocutaneous syndrome 4 (CFC4), a multiple congenital anomaly disorder characterized by a distinctive facial appearance, heart defects, and mental retardation.

Other Names:

Dual specificity mitogen-activated protein kinase kinase 2, MAP kinase kinase 2, MAPKK 2, ERK activator kinase 2, MAPK/ERK kinase 2, MEK 2, MEK2, MKK2, PRKMK2

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing C-terminal region of human MAP2K2. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: