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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 22 kDa                                                            Uniprot ID: Q9HAF1

Background:

MYST/Esa1-associated factor 6 (MEAF6) is a nuclear protein involved in transcriptional activation. MEAF6 is a component of the NuA4 histone acetyltransferase complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. MEAF6 is also a component of the HBO1 complex, which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo.

Other Names:

C1orf149, EAF6, Sarcoma antigen NY-SAR-91, hEAF6, Protein EAF6 homolog, Esa1-associated factor 6 homolog, Chromatin modification-related protein MEAF6, MYST/Esa1-associated factor 6, CENP-28, FLJ11730, NY-SAR-91

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human MEAF6. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN₃. Store at -20 °C. Stable for 6 months from date of receipt.

Species Specificity:

Human, Mouse

Tested Applications:

WB: 1:1,000-1:3,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Product Data: