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R1911-1 - COMMD1 (M) Antibody, Rabbit Polyclonal
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Quantity: 100 ul Application: WB Predicted I Observed M.W.: 21 I 25 kDa Uniprot ID: Q8N668 Background: COMM domain-containing protein 1 (COMMD1) promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. COMMD1 down-regulates NF-kappa-B activity. COMMD1 also down-regulates SOD1 activity by interfering with its homodimerization. COMMD1 plays a role in copper ion homeostasis and can bind one copper ion per monomer. COMMD1 may function to facilitate biliary copper excretion within hepatocytes Other Names: COMM domain-containing protein 1, Protein Murr1, C2orf5, MURR1, MGC27155 Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the middle region of human COMMD1. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human, Mouse Tested Applications: WB: 1:1,000-1:3,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. Product Data: Fig 1. Western blot of total cell extracts fromA) mouse thymus, B) human HeLa, C) human Jurkat; using anti-COMMD1 (M) (R1911-1) at RT for 2 h. |