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Quantity: 100 ul                                                                                          Application: WB

Predicted I Observed M.W.: 119 kDa                                                          Uniprot ID: O00329

Background:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIk3CD) is a phosphoinositide-3-kinase (PI3K) that phosphorylates PftdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, to activate signaling cascades involved in cell growth, survival, proliferation, motility and morphology. PIK3CD mediates immune responses. PIK3CD is required for B-cell receptor (BCR) signaling and plays a role in B-cell development, proliferation, migration, and function. PIK3CD is also required for T-cell receptor (TCR) signaling and proliferation, signaling and cytokine production of naive, effector and memory T-cells. Together with PIK3CG, PIK3CD is involved in natural killer (NK) cell development, maturation and function.

Other Names:

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, PI3-kinase subunit delta, PI3K-delta, PI3Kdelta, PtdIns-3-kinase subunit delta, Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta, PtdIns-3-kinase subunit p110-delta, p110delta

Source and Purity:

Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the N-terminal region of human PIK3CD. Antibodies were purified by affinity purification using immunogen. 

Storage Buffer and Condition:

Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt.

Tested Applications: 

WB: 1:500-1:2,000 (detect endogenous protein*)

*: The apparent protein size on WB may be different from the calculated M.W. due to modifications.

Species Specificity:

Human, Mouse

Product Data: